Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (3): 467-469    DOI: 10.12891/ceog3357.2017
Case Report Previous articles | Next articles
Successful live birth in a patient who underwent cranial radiotherapy and systemic chemotherapy by implantation of a cryopreserved blastocyst on day 7
C. Hayashi1, *(), F. Chishima1, K. Matsumoto1, E. Kato1, K. Shinya1, T. Nakao1, A. Nakamura1, T. Yamamoto1
1 Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan
Download:  PDF
Export:  BibTeX | EndNote (RIS)      
Abstract  Preservation of fertility has been recommended for cancer-bearing patients of reproductive age before undergoing cancer treatment. However, there are many considerations and it is difficult to preserve fertility for all patients undergoing therapy for malignancies. Female cancer survivors had lower pregnancy and live birth rates compared with others that underwent assisted reproductive technologies (ARTs). We should continue to consider the issue of infertility in patients who underwent therapies for malignancies. This is the first report of a successful live birth in a patient with a cranial tumor who underwent radiotherapy and chemotherapy after implantation of an autologous embryo. The patient was a 27-year-old Japanese woman. She was diagnosed with suprasellar germinoma at 13 years of age, and she developed panhypopituitarism after radiotherapy and chemotherapy. At 27 years of age, she began infertility treatment with in-vitro fertilization (IVF). The level of anti-Mullerian hormone (AMH) was 4.29 ng/ml. After ovarian stimulation by high purified human menopausal gonadotropin (HP-hMG), she obtained two blastocysts and became pregnant by implantation of a cryopreserved blastocyst. At 37 gestational weeks, she delivered a healthy female baby by cesarean section.
Key words:  Cranial tumor      Irradiation      Chemotherapy      Infertility      AMH      Live birth     
Published:  10 June 2017     
*Corresponding Author(s):  C. HAYASHI     E-mail:  hayashi.chuyu@nihon-u.ac.jp

Cite this article: 

C. Hayashi, F. Chishima, K. Matsumoto, E. Kato, K. Shinya, T. Nakao, A. Nakamura, T. Yamamoto. Successful live birth in a patient who underwent cranial radiotherapy and systemic chemotherapy by implantation of a cryopreserved blastocyst on day 7. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(3): 467-469.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3357.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I3/467

[1] B.G. Kadioglu, B. Gundogdu, N. Kurt, A. Ozbek Bilgin, H. Suleyman, Z. Suleyman. The effect of rhodiola rosea root extract on stress-induced ovarian damage, infertility and reproductive disorders in female rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 530-536.
[2] S. J. Knight, A. D. Smith, H. Kim, A. C. Collier. Human placental suppressors of cytokine signalling (SOCS) and inflammatory cytokines are dysregulated in assisted reproduction, advanced maternal age and pre-term birth[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 277-286.
[3] J. Huang, Z. Zhang. Spontaneous umbilical cord vascular rupture before labor for congenital defects with a live birth: a case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 142-143.
[4] Hue HJ, Kim SK, Choi JY, Suh DH, Kim KD, No JH, Lee JR, Jee BC, Kim YB, Jeon HW. Previous ovarian surgery increases the risk of tubal factor infertility[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 84-88.
[5] M. Minase, T. Miyamoto, N. Hayashi, G. Minase, K. Nishiwaki, K. Sengoku. A patient with a didelphys vaginal septum and infertility diagnosed by laparoscopy and magnetic resonance imaging[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 988-989.
[6] M. Englert-Golon, N. Smolarek, B. Burchardt, R. Słopień, S. Sajdak. A case of cervical cancer diagnosed during pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 1005-1006.
[7] E.G. Aydeniz, U. Sari, T.U.K. Dilek. Pregnancy success rate at recurrent implantation failure patients after hysteroscopic endometrial injury: preliminary study[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 709-712.
[8] J. Jeong, J. Yang, Y. J. Song, Y. J. Na, H. G. Kim. A case report of acute ovarian cyst torsion by female adnexal tumor of probable Wölffian origin[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 824-827.
[9] K. Kitaya, Y. Takaya, R. Nishiyama, K. Yamaguchi, H. Matsubayashi, T. Takeuchi, S. Mizuta, T. Ishikawa. Myoinositol supplementation on intracytoplasmic sperm injection outcome in Japanese infertile polycystic ovarian syndrome women with non-obese less-androgenic phenotype: a prospective controlled observational study[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 549-552.
[10] H. Kwon, J. E. Shin, H. Kim. A novel treatment of severe dysmenorrhea due to adenomyosis: a case series of 3 infertile patients treated with dopamine agonist and in vitro fertilization-embryo transfer resulting in successful pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 637-640.
[11] P. Fuchs, I. Czech, A. Fuchs, J. Sikora. Use of neutral argon plasma in the treatment of endometriosis initial findings[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(3): 434-436.
[12] J.H. Check, J. Liss, D. Check. The beneficial effect of luteal phase support on pregnancy rates in women with unexplained infertility[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(3): 447-449.
[13] I. Rudic Biljic-Erski, M. Vasiljevic, S. Rakic, S. Mihajlovic, O.D. Smiljkovic. The impact of hysteroscopic myomectomy on fertility and pregnancy outcomes of infertile women according characteristics of submucous fibroids[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 235-240.
[14] Z. Kalem, M.N. Kalem, N. Akgün, A.E. Kaya, B. Bakirarar, S. Aydın. The relationship between the levels of anti-Müllerian hormone, vaspin, visfatin, and the patterns of nutrition and menstruation in non-polycystic ovary syndrome and non-obese young women[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 258-264.
[15] Chunjuan Shen, Liping Wang, Xiaojie Wu, Shuhui Mao, Chunxia Fang. The relationship between vitamin D and IVF: a systematic review and meta-analysis[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 12-15.
No Suggested Reading articles found!