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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (3): 332-333    DOI: 10.12891/ceog3232.2016
Original Research Previous articles | Next articles
Failure to increase the thickness of thin endometria with intrauterine infusion of granulocyte colony stimulating factor (G-CSF)
J. H. Check1, 2, *(), J. K. Choe1, D. Summers-Chase2
1Cooper Medical School of Rowen University Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Camden, NJ
2Cooper Institute For Reproductive Hormonal Disorders, P.C. Marlton, NJ (USA)
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Abstract  
Purpose: To corroborate or refute a previous study suggesting that intrauterine infusion of granulocyte colony stimulating factor (GCSF) could significantly improve endometrial thickness into more fertile levels when the endometrial thickness was ≤ five mm. Materials and Methods: Three women whose endometrial thickness never exceeded five mm on the in vitro fertilization-embryo transfer(IVF-ET) cycle or subsequent attempted frozen ETs using graduated estradiol had intrauterine infusion of G-CSF to the estradiol regimen. Results: Not one of the three women improved the endometrial thickness beyond five mm and none conceived on the G-CSF cycle. One woman had a subsequent pregnancy following a frozen ET with only a four-mm thickness with no infusion of G-CSF. Conclusions: These data do not confirm the efficacy of intrauterine infusion of G-CSF for poor endometrial thickness. Perhaps only certain cases will respond. A larger series could take time to accumulate since other studies have shown that only 0.3% of women with ≤ five mm endometrial thickness in the late proliferative phase during an IVF-ET cycle will not improve the endometrial thickness > five mm using graduated estradiol protocols.
Key words:  Endometrial thickness      Granulocyte-colony stimulating factor (G-CSF)      Graduated estradiol therapy     
Published:  10 June 2016     
*Corresponding Author(s):  J. H. CHECK     E-mail:  laurie@ccivf.com

Cite this article: 

J. H. Check, J. K. Choe, D. Summers-Chase. Failure to increase the thickness of thin endometria with intrauterine infusion of granulocyte colony stimulating factor (G-CSF). Clinical and Experimental Obstetrics & Gynecology, 2016, 43(3): 332-333.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3232.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I3/332

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