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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (3): 328-329    DOI: 10.12891/ceog3231.2016
Original Research Previous articles | Next articles
Efficacy of a single injection of human chorionic gonadotropin at peak follicular maturation in natural cycles on pregnancy rate and mid-luteal hormonal and sonographic parameters
J. H. Check1, 2, *(), J. R. Liss2, G. DiAntonio2, D. Summers2
1Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ
2Cooper Institute for Reproductive Hormonal Disorders, P.C., Mt. Laurel, NJ (USA)
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Abstract  
Purpose: To discover if infertile women with presumed luteal phase deficiency would improve pregnancy rates, mid-luteal sera estradiol (E2) and progesterone (P), and increase the percentage of women achieving a mid-luteal sonographic homogeneous hyperechogenic endometrial texture by the addition of a single injection of human chorionic gonadotropin (hCG). Materials and Methods: Women with over one year of infertility with regular menses and with no other known infertility factor were presumed to have the need for extra P in the luteal phase based on previous studies. Women aged ≥ 30 years were selected along with women < 30 years who had pelvic pain or dysmenorrhea. Women aged 40-45 were evaluated separately. They were treated with either vaginal micronized P 8% twice daily alone or 10,000 units of hCG at the time of peak follicular maturation was also given. Women were eliminated if they did not achieve an 18-24 average diameter follicle with a serum E2 of > 200 pg/ml. Seven days after ovulation, sera E2 and P were measured along with endometrial thickness and echo patterns. Results: The only significant difference between groups was an increased mid-luteal serum E2 in the group receiving additional hCG. However, this did not result in an increased pregnancy rate. Conclusions: In general, adding a single injection of hCG to P luteal support does not improve pregnancy rates in natural cycles where women were treated with supplemental P.
Key words:  Human choronic gonadotropin      Progesterone      Luteal phase defect      Homogeneous hyperechogenic endometrial echo pattern      Endometrial thickness      Serum estradiol     
Published:  10 June 2016     
*Corresponding Author(s):  J. H. CHECK     E-mail:  laurie@ccivf.com

Cite this article: 

J. H. Check, J. R. Liss, G. DiAntonio, D. Summers. Efficacy of a single injection of human chorionic gonadotropin at peak follicular maturation in natural cycles on pregnancy rate and mid-luteal hormonal and sonographic parameters. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(3): 328-329.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3231.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I3/328

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