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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (2): 178-180    DOI: 10.12891/ceog3229.2016
Original Research Previous articles | Next articles
The use of granulocyte colony stimulating factor to enhance oocyte release in women with the luteinized unruptured follicle syndrome
J. H. Check1, 2, *(), J. Vaniver2, D. Senft2, G. DiAntonio2, D. Summers2
1Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ
2Cooper Institute for Reproductive Hormonal Disorders, P.C., Mt. Laurel, NJ (USA)
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Abstract  
Purpose: To determine if an injection of granulocyte colony stimulating factor (G-CSF) prevoulatory can enable oocyte release from the follicle in women who have failed to release in natural cycles despite an endogenous luteinizing hormone (LH) surge, and also despite treatment with human chorionic gonadotropin (hCG) or a gonadotropin releasing hormone agonist (GnRHa). Materials and Methods: A single injection of 100 mg G-CSF was given in the late follicular phase followed by hCG 10,000 units at peak follicular maturation in women with at least three consecutive cycles of luteinization without oocyte release. Results: Six women had ten cycles with G-CSF and hCG. Definite release occurred in four, inconclusive in four, and definitely the luteinized unruptured follicle in two. Biochemical pregnancies occurred in two of the cycles where oocyte release occurred and a live delivered pregnancy in another cycle of release. Conclusions: Without controls one cannot state with certainty that G-CSF enabled oocyte release when hCG and leuprolide failed. Nevertheless, the data do support a trial with G-CSF before proceeding to IVF-ET.
Key words:  Luteinized unruptured follicle syndrome      Granulocyte colony stimulating factor      Human chorionic gonadotropin      Gonadotropin releasing hormone agonists      Natural cycles     
Published:  10 April 2016     
*Corresponding Author(s):  JEROME H. CHECK     E-mail:  laurie@ccivf.com

Cite this article: 

J. H. Check, J. Vaniver, D. Senft, G. DiAntonio, D. Summers. The use of granulocyte colony stimulating factor to enhance oocyte release in women with the luteinized unruptured follicle syndrome. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(2): 178-180.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3229.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I2/178

[1] J.H. Check, M.P. Dougherty. Injection of human chorionic gonadotropin (hCG) can cause the luteinized unruptured follicle syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 635-636.
[2] J.H. Check. Intractable severe peri-ovulatory sneezing abrogated by injection of human chorionic gonadotropin[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 781-781.
[3] M. Zu, G.Q. Zhao, Z.Q. Liu, H.T. Zhang, L. Chen, D.H. Zhao. A case report of a patient with high β-hCG levels after operation because of primary broad ligament pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(1): 138-142.
[4] T. Fukami, H. Tsujioka, S. Matsuoka, S. Sorano, A. Tohyama, H. Yamamoto, S. Nakamura, M. Goto, R. Matsuoka, F. Eguchi. Rupture risk factors of fallopian tubal pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(6): 800-802.
[5] S. Olgan, G. Bozdag, L. K. Sokmensuer, S. Mumusoglu, S. Gunalp. Revisiting serum beta-human chorionic gonadotropin concentrations as a predictor for dizygotic twinning after in vitro fertilization[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(4): 597-601.
[6] J.H. Check, C. Wilson, R. Cohen, J.K. Choe, D. Corley. Mid-luteal phase injection of subcutaneous leuprolide acetate improves live delivered pregnancy and implantation rates in younger women undergoing in vitro fertilization-embryo transfer (IVF-ET)[J]. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(4): 427-428.
[7] B.S. Unlu, H. Energin, Y. Yildiz, E. Unlu, E.G. Yapar Eyi. Maternal serum pregnancy-associated plasma protein-A levels in hyperemesis gravidarum: a prospective case control study[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(5): 534-536.
[8] J.H. Check, J. Liss, R. Cohen. A comparison of three types of therapies for three different ovulation disorders in establishing pregnancies and evaluation of laboratory parameters that could influence the outcome[J]. Clinical and Experimental Obstetrics & Gynecology, 2013, 40(3): 317-318.
[9] J.H. Check. Mild increases in serum FSH in late follicular phase increases the risk of the luteinized unruptured follice: case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2013, 40(3): 433-434.
[10] J.H. Check, J. Liss. The effect of diminished oocyte reserve in younger women (age ≤ 37) on pregnancy rates in natural cycles[J]. Clinical and Experimental Obstetrics & Gynecology, 2013, 40(1): 27-28.
[11] J.H. Check. Luteal phase support for in vitro fertilization-embryo transfer – present and future methods to improve successful implantation[J]. Clinical and Experimental Obstetrics & Gynecology, 2012, 39(4): 422-428.
[12] J.H Check, J.K. Choe, J. Amui, D. Brasile. Association of the change in serum estradiol (E2) levels from the day of to the day after human chorionic gonadotropin (hCG) injection and pregnancy outcome following in vitro fertilization-embryo transfer (IVF-ET) in less than average responders[J]. Clinical and Experimental Obstetrics & Gynecology, 2010, 37(2): 110-111.
[13] J.H. Check. A practical approach to the prevention of miscarriage: Part 1 - progesterone therapy[J]. Clinical and Experimental Obstetrics & Gynecology, 2009, 36(4): 203-208.
[14] J. H. Check. Ovulation defects despite regular menses: part III[J]. Clinical and Experimental Obstetrics & Gynecology, 2007, 34(3): 133-136.
[15] F. Borruto, C. Comparetto, L. Acanfora, G. Bertini, F. F. Rubaltelli. Role of ultrasound evaluation of nuchal translucency in prenatal diagnosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2002, 29(4): 235-241.
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