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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (1): 39-43    DOI: 10.12891/ceog3180.2017
Original Research Previous articles | Next articles
Predictive value of procalcitonin and IL-6 versus cervical length for the admission-to-delivery interval in preterm labour
S. Nergiz Avcioğlu1, *(), S. Ö. Altinkaya1, S. Demi̇rcan Sezer1, İ.K. Ömürlü2, M. Küçük3, H. Yüksel1
1 Department of Gynecology and Obstetrics, Adnan Menderes University, School of Medicine, Aydın, Turkey
2 Department of Biostatistics, Adnan Menderes University, School of Medicine Aydın, Turkey
3 Department of Gynecology and Obstetrics, Muğla Sıtkı Koçman University, School of Medicine, Muğla, Turkey
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Abstract  
Objective: The authors aimed to determine whether concentrations of IL-6 and procalcitonin in maternal circulation can be used and compared with cervical length to predict the admission-to-delivery interval in preterm labour. Materials and Methods: Forty patients complicated with preterm labour between 24-34 weeks of gestation and having preterm birth were included in the study group. Fortyfour healthy pregnant women at similar gestational ages and having term labour (≥ 37 weeks) were included in control group. Maternal concentrations of IL-6 was measured by an enzyme-linked immunosorbent assay (ELISA) and procalcitonin was measured by immunoturbidimetry with using human procalcitonin reagent kit. Transvaginal ultrasound to assess cervical length was performed. Results: Receiver operator characteristic (ROC) analysis results of IL-6 and procalcitonin for prediction of preterm delivery (PTD) < 48 hours, < seven days, < 32 weeks, < 34 weeks, and < 37 weeks were not statistically significant (p > 0.05). ). It was shown through ROC analysis, that only cervical length had area under curve (AUC) 0.692 (0.511–0.873, p = 0.044) at cut off value ≤ 3.64 cm, AUC 0.758 (0.574–0.943, p = 0.015) at cut off value ≤ 3.50 cm, AUC 0.716 (0.553–0.879, p = 0.032) at cut off value < 3.80 cm, in predicting PTD within seven days, < 32 weeks and < 37 week, respectively. Conclusion: This study suggests that in preterm labour, although IL-6 and procalcitonin have unsatisfactory predictive value for the admission-to-delivery interval, cervical length has better predictive values for the admission-to-delivery interval.
Key words:  Procalcitonin      IL-6      Cervical length      Preterm labour      Preterm delivery     
Published:  10 February 2017     
*Corresponding Author(s):  S. NERGİZ AVCIOĞLU     E-mail:  sumeyranergiz80@gmail.com

Cite this article: 

S. Nergiz Avcioğlu, S.Ö. Altinkaya, S. Demi̇rcan Sezer, İ.K. Ömürlü, M. Küçük, H. Yüksel. Predictive value of procalcitonin and IL-6 versus cervical length for the admission-to-delivery interval in preterm labour. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(1): 39-43.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3180.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I1/39

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