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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (2): 254-257    DOI: 10.12891/ceog2768.2016
Original Research Previous articles | Next articles
-1195 A/G promoter variants of the cyclooxygenase-2 gene increases the risk of pain occurrence in endometriotic women
H. Wang1, *(), L. Sun1, M. Jiang1, L. Liu1, G. Wang1
1Department of Gynecology, Dalian Hospital of Gynecology and Obstetrics, Dalian (China)
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Abstract  
Objective: The aim of this study was to evaluate the association between -1195 A/G polymorphism in cyclooxygenase -2 (COX-2) gene and the risk of pain occurrence in women with endometriosis (EM). Materials and Methods: -1195 A/G polymorphism in the promoter region of COX-2 gene was analyzed in 32 EM patients with pain, 28 EM patients without pain, and 29 healthy controls in a Chinese population using a PCR-RFLP assay. Results: AA homozygote carriers and A allelic frequencies for -1195 A/G polymorphism in COX-2 gene were significantly increased in EM patients compared with the healthy controls (p < 0.001). In addition, further subgroup analysis revealed that the AA genotype and A allele of the -1195 A/G variant were present at a significantly higher frequency in the severe pain group than those in the mild and moderate pain groups. Compared with the controls, the risk of developing EM was 2.86-fold higher in individuals with -1195 AA containing the haplotype, and the risk of developing pain was 2.33-fold higher in EM patients with -1195 AA containing the haplotype. Conclusions: These findings suggest that the -1195 A/G on the promoter region of COX-2 gene may increase the risk of pain occurrence in EM women, possibly by affecting the rate of gene expression, especially in patients with the pain phenotype.
Key words:  Endometriosis      Pain      Cyclooxygenase-2      Single nucleotide polymorphism     
Published:  10 April 2016     
*Corresponding Author(s):  H. WANG     E-mail:  hualiwangcn@163.com

Cite this article: 

H. Wang, L. Sun, M. Jiang, L. Liu, G. Wang. -1195 A/G promoter variants of the cyclooxygenase-2 gene increases the risk of pain occurrence in endometriotic women. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(2): 254-257.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog2768.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I2/254

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