Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (3): 463-466    DOI: 10.12891/ceog2150.2016
Case Report Previous articles | Next articles
The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis
R. Bedir1, *(), I. Sehitoglu1, G. Balik2, M. Kagitci2, H. Gucer1, C. Yurdakul1, P. Bagci3
1Recep Tayyip Erdogan University, Faculty of Medicine, Department of Pathology, Rize
2Recep Tayyip Erdogan University, Faculty of Medicine, Department of Obstetrics and Gynecology, Rize
3Marmara University, Faculty of Medicine, Department of Pathology, Istanbul (Turkey)
Download:  PDF(272KB)  ( 5 )
Export:  BibTeX | EndNote (RIS)      
Abstract  
Objective: Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in normal endometrium and in ectopic endometriotic tissues. Materials and Methods: Nectin-4 expression was investigated in ovarian endometriosis (n=20), peritoneal endometriosis (n=20), endometriumof endometriosis (n=20), and in a control group (having no endometriosis) (n=20) by immunohistochemical method. Results: Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 and p = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011). Conclusion: The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful.
Key words:  Endometriosis      Nectin-4      Immunohistochemistry     
Published:  10 June 2016     
*Corresponding Author(s):  R. BEDIR     E-mail:  bedirrecep@gmail.com

Cite this article: 

R. Bedir, I. Sehitoglu, G. Balik, M. Kagitci, H. Gucer, C. Yurdakul, P. Bagci. The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(3): 463-466.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog2150.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I3/463

[1] Jian-Zhong Pan, Yan Tang, Ling Li, Xin-Yue Xu, Xiao Cheng, Yuan-Yuan Chen. “Umbilical mass”: a case of primary umbilical endometriosis and literature review[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1227-1231.
[2] Sayuli Bhide, Rebecca Flyckt, Meng Yao, Tommaso Falcone. Long-term impact of chronic pelvic pain on quality of life in women with and without endometriosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 851-859.
[3] Xi-Wa Zhao, Meng-Meng Zhang, Jian Zhao, Wei Zhao, Shan Kang. Correlative factors associated with the recurrence of ovarian endometriosis: a retrospective study[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 962-968.
[4] Saša Raičević, Duško Kljakić, Filip Vukmirović, Miloš Z. Milosavljević. A giant placental chorioangioma with a resultant live birth; a discussion of management options[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 426-430.
[5] Xiao Zhang, Ying-Ying He, Nan Jiang, Zhi-Gang Sun, Feng Yan, Cidanyangzong, Fang Long, Fang-Xin Shi, Xiao-Guang Xu, Zhen Xiao. The infiltrating ability of abdominal wall endometriosis is associated with ectopic endometrial glandular activity[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 73-78.
[6] Masataka Ono, Junya Kojima, Ei Hasegawa, Yotaro Takaesu, Toru Sasaki, Hirotaka Nishi. Anti-Müllerian hormone levels following laparoscopic ovarian cystectomy with subcutaneous abdominal wall lifting for ovarian endometriomas[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 91-97.
[7] L. Lamprou, G. Panagopoulou, N. Papadopoulos, C. Tsigalou, O. Pagonopoulou, M. Lambropoulou. Impact of chorioamnionitis and other intrauterine pathological conditions on human foetal cytoskeleton structural protein development: An immunohistochemical study[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 856-861.
[8] D. Filipecka-Tyczka, A. Kajdy, B.P. Siekierski, M. Stańczyk, A. Rogowski, M. Rabijewski, R.B. Maksym. Deep infiltrating endometriosis as a cause of severe urogynecological complications despite invasive treatment - report of two cases from the center of endometriosis surgery[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 955-960.
[9] Y.A. Kim. Mature cystic teratoma of the uterus presenting as an endometrial polyp in a patient with a history of ovarian mature cystic teratoma with gliomatosis peritonei and ovarian endometriosis: a case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 800-804.
[10] H. Takagi, S. Yamada, J. Sakamoto, S. Fujita, T. Sasagawa. Hemostatic effects of kyukikyogaito in dienogest treatment[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 560-564.
[11] K. Chmaj-Wierzchowska, M. Wojciechowska, I. Parda, K. Plagens-Rotman, P. Rzymski, M. Wilczak. How do health problems affect the quality and everyday life of patients with endometriomas?[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 571-575.
[12] X.J. Shi, L.B. Shi, S.Y. Zhang. Mechanistic study of vitamin C attenuation of endometriotic fibrosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(3): 383-390.
[13] M. Ζafrakas, Κ. Κοtronis, P. Papasozomenou, P. Eskitzis, G. Grimbizis. Extracellular matrix metalloproteinases in the etiopathogenesis of endometriosis: a systematic review and critical appraisal[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 147-153.
[14] K.Y. Yun, S.Y. Hwang, H.J. Lee, S.C. Kim, J.K. Joo, D.S. Suh, K.H. Kim, K.S. Lee. The association of body mass index with incidence, stage and recurrence of endometriosis: case-control study in Korean women[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 53-56.
[15] Hue HJ, Kim SK, Choi JY, Suh DH, Kim KD, No JH, Lee JR, Jee BC, Kim YB, Jeon HW. Previous ovarian surgery increases the risk of tubal factor infertility[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 84-88.
No Suggested Reading articles found!