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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (4): 529-533    DOI: 10.12891/ceog2114.2016
Original Research Previous articles | Next articles
Effects of aloe vera gel on the induction of endometriosis and regression of endometrial explants in a rat model
M. S. Bostanci1, *(), M. Bakacak2, Ö. Kizilkale Yildirim3, G. Yildirim3, R. Attar3, F. Özkan4, F. İnanc Tolun5
1Department of Obstetrics and Gynecology, Sakarya University Faculty of Medicine Research and Educational Hospital, Sakarya
2Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaraş
3Department of Obstetrics and Gynecology, Yeditepe University, Faculty of Medicine, Istanbul
4Department of Pathology, Yeditepe University, Faculty of Medicine, Istanbul
5Department of Biochemistry, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaraş (Turkey)
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Abstract  
Purpose of investigation: To evaluate the preventive and reducing effect of aloe vera gel on surgically-induced endometrial foci in rats. Materials and Methods: Twenty-four reproductive aged female non-pregnant, nulligravid Sprague-Dawley albino rats were used. The rats were randomly divided to three groups (Group 1: control, Group 2: aloe vera endometriosis formation, and Group 3: aloe vera endometriosis treatment). A peritoneal lavage using one-ml saline was taken at all the operations for determination of superoxide dismutase (SOD), malondialdehyde (MDA), and catalase (CAT). Forty-eight horns were implanted in 24 rats. Results: All the implants were properly formed after implantation. In Group 3, before aloe vera application, the sum of the volumes was 87.2 ± 20.4 mm3 and after treatment the volumes dropped to 28.9 ± 14.9 mm3 (p = 0.01). As evaluation of aloe vera on the formation of endometriosis in the second operation in Group 2, the sum of the volumes was 2.9±1.4 mm3 and in Group 1, 118.9 ± 20.0 mm3(p = 0.001). Likewise, similar changes were observed in the histopatological scores. Conclusion: The application of aloe vera was seen to raise antioxidant levels in the peritoneal fluid and to reduce oxidative stress markers. Aloe vera is effective in the inhibition of formation and regression of endometriotic lesions.
Key words:  Aloe vera      Endometriosis      Oxidative stress     
Published:  10 August 2016     
*Corresponding Author(s):  M. S. BOSTANCI     E-mail:  msuhha@gmail.com

Cite this article: 

M. S. Bostanci, M. Bakacak, Ö. Kizilkale Yildirim, G. Yildirim, R. Attar, F. Özkan, F. İnanc Tolun. Effects of aloe vera gel on the induction of endometriosis and regression of endometrial explants in a rat model. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(4): 529-533.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog2114.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I4/529

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