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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (2): 245-249    DOI: 10.12891/ceog2091.2016
Original Research Previous articles | Next articles
Early fetal heart ultrasonography as additional indicator for chromosomopathies
A. Dmitrovic1, K. Jeremic1, 2, U.M. Babic1, M. Perovic4, T. Mihailovic3, D. Opric1, 5, N. Zečevic4, M. Gojnić-Dugalić1, 2, *()
1Clinical Center of Serbia, Clinic of Obstetrics and Gynecology, Belgrade
2Medical Faculty, University of Belgrade, Belgrade, Belgrade
3Ultramedica Clinic, US Medical School, Belgrade
4University Clinic of Gynecology and Obstetrics "Narodni front", Belgrade
5Institute of Pathology, Medical faculty University of Belgrade, Belgrade (Serbia)
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Abstract  
Objective: First trial of estimating values of scans of fetal heart structures (FHS) in first trimester of pregnancy, as more primary facts of possible chromosomopathies. Materials and Methods: The study included 2,643 fetuses that were examined in first trimester of pregnancy on Sono CT convex (C5-2MHz), endovaginal (ev 8-4MHz), and linear transducers (L12-5MHz) during a period of eight years. Fetal heart was evaluated using appropriate software with broad-band transducers and color Doppler, Sono CT, and HD ZOOM technologies. The scan was performed by three experienced physicians. FHS were based on: left and right ventricle morphology; AV valves (atrioventricular) position and existence of primal ostium; relationship of left ventricle outflow tract (LVOT) and right ventricle outflow tract (RVOT) and great vessels on three vessel view (3VV) and estimation of ductal and aortic arch. Results: Several developments, one being the ability to identify fetuses at risk for cardiac defects combining nuchal translucency (NT), ductus venosus (DV) Doppler, and evaluation of tricuspid regurgitation, have prompted reconsideration of the role of the first trimester prognostic factor of fetal evaluation. In low-risk pregnancies group, 36 (1.8%) fetuses were found to have congenital heart disease (CHD), and in high-risk pregnancies the number of fetuses with CHD was 75 (12%). Genetic amniocentesis or chorionic villus sampling (CVS) was performed in all fetuses with CHD. Forty-two (37.8%) fetuses with CHD were found to have chromosomal anomalies. Out of 111 fetuses with CHD 39 (35.1%) had an nuchal translucency (NT) above three mm. Out of 42 fetuses with chromosomal anomalies and CHD, 29 (69%) had an increased NT. Conclusion: Using first trimester fetal echosonography constitutes a further step in the earlier recognition of chromosomopathies, even in low risk groups. Still further steps are necessary as all facts of good clinical practice. In order to offer further benefits during pregnancies, improvements in diagnostics are still required.
Key words:  Chromosomopathies      First trimester      Early diagnosis      Fetal echocardiography      Cardiac defects     
Published:  10 April 2016     
*Corresponding Author(s):  M. GOJNIĆ DUGALIĆ     E-mail:  miroslavagojnicdugalic@yahoo.com

Cite this article: 

A. Dmitrovic, K. Jeremic, U.M. Babic, M. Perovic, T. Mihailovic, D. Opric, N. Zečevic, M. Gojnić-Dugalić. Early fetal heart ultrasonography as additional indicator for chromosomopathies. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(2): 245-249.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog2091.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I2/245

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