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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (1): 98-102    DOI: 10.12891/ceog2039.2016
Original Research Previous articles | Next articles
The possible role of serum leptin in preeclampsia
Y. Doster1, B. Cetinkaya Demir2, M.A. Atalay2, *(), E.E. Durusoy2, S. Kucukkomurcu2
1Department of Obstetrics and Gynecology, Medipol University School of Medicine, Istanbul
2Department of Obstetrics and Gynecology, Uludag University School of Medicine, Bursa (Turkey)
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Abstract  
Background: It is theorized that adipokines play a critical role in the pathophysiology of preeclampsia, particularly with their pro-inflammatory and inflammatory features. Aim: To investigate serum leptin levels in pregnancies complicated with preeclampsia and severe preeclampsia. Materials and Methods: Maternal serum leptin levels were analyzed by solid phase enzyme amplified sensitivity immunoassay (EASIA) method in 23 patients with mild preeclampsia, 29 patients with severe preeclampsia, and 28 healthy pregnant controls. Results: Mean serum leptin levels did not differ statistically between patients with mild preeclampsia, severe preeclampsia, and the controls (10.77 ng/ml, 13.40 ng/ml, and 8.43 ng/ml, respectively). Also, there was no relationship between serum leptin levels and the gestational ages of the participants. Discussion: Serum leptin levels are not associated with preeclampsia. Leptin measurements are not affected with the gestational age. The role of leptin in the pathophysiology of preeclampsia should be evaluated cautiously.
Key words:  Preeclampsia      Severe preeclampsia      Adipokine      Leptin     
Published:  10 February 2016     
*Corresponding Author(s):  M.A. ATALAY     E-mail:  maralatalay@gmail.com

Cite this article: 

Y. Doster, B. Cetinkaya Demir, M.A. Atalay, E.E. Durusoy, S. Kucukkomurcu. The possible role of serum leptin in preeclampsia. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(1): 98-102.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog2039.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I1/98

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