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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (1): 82-87    DOI: 10.12891/ceog2037.2016
Original Research Previous articles | Next articles
Histopathology of ipsilateral and contralateral ovaries and plasma interleukin 6 levels after unilateral ovarian torsion
L. Karakoc-Sokmensuer1, 2, *(), S. Hacivelioglu3, A. Demir4, M. Kose5, F.F. Kaymaz1, D.U. Cakir6, G. Bozdag2
1Department of Histology and Embryology, School of Medicine, Hacettepe University, Ankara
2Department of Obstetrics and Gynecology, School of Medicine, Hacettepe University, Ankara
3Department of Obstetrics and Gynecology, School of Medicine, Onsekiz Mart University, Canakkale
4Elazığ Training and Research Hospital, Department of Obstetrics and Gynecology, Elaziğ
5Afyon State Hospital, Department of Obstetrics and Gynecology, Afyon
6Department of Clinical Biochemistry, School of Medicine, Onsekiz Mart University, Canakkale (Turkey)
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Abstract  
Objective: The aim of the present study was to evaluate the time-dependent histopathologic changes in both ovaries and to determine the time-dependent levels of plasma interleukin 6 (IL-6) after unilateral ovarian torsion. Materials and Methods: An experimental animal study included 48 female Sprague-Dawley rats which were distributed to six groups: control group (Group 1), sham-operated control group (Group 2), and four unilateral ovarian torsion groups with torsion duration of three, six, 12, and 24 hours (Group 3, 4, 5, and 6, respectively). Histopathologic criteria (follicular degeneration, vascular congestion, hemorrhage, inflammatory cell infiltration, and total tissue damage score) were evaluated in both ovaries, and plasma IL-6 levels were measured. Results: At 24 hours after torsion began, mean total tissue damage score was similar between ovaries that had torsion and contralateral ovaries. Mean plasma IL-6 level did not change during the 24 hours after torsion began (p = 0.584). Conclusions: In addition to ovaries that had torsion, histopathologic abnormalities also occurred in contralateral ovaries. These results suggest that contralateral ovaries are not quiescent after unilateral ovarian torsion. Plasma IL-6 levels did not change significantly during the 24 hours after ovarian torsion began, resulting in a limitation of its diagnostic use in the early course of the disease.
Key words:  Acute abdominal pain      Surgical emergency      Biomarkers      Cytokines     
Published:  10 February 2016     
*Corresponding Author(s):  L. KARAKOC-SOKMENSUER     E-mail:  lalekarakoc@hacettepe.edu.tr

Cite this article: 

L. Karakoc-Sokmensuer, S. Hacivelioglu, A. Demir, M. Kose, F.F. Kaymaz, D.U. Cakir, G. Bozdag. Histopathology of ipsilateral and contralateral ovaries and plasma interleukin 6 levels after unilateral ovarian torsion. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(1): 82-87.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog2037.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I1/82

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