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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (1): 75-81    DOI: 10.12891/ceog2027.2016
Original Research Previous articles | Next articles
Expression and significance of ERβ and TrkB in endometriosis
X. Yu1, *(), H. Ren2, T. Liu3, M. Yong4, H. Zhong3
1Department of Gynecology, Dalian Obstetrics and Gynecology Hospital Affiliated to Dalian Medical University, Dalian
2Department of General Surgery of Dalian Friendship Hospital Affiliated to Dalian Medical University, Dalian
3Department of Pathology of Dalian Friendship Hospital Affiliated to Dalian Medical University, Dalian
4Dalian Medical University Graduate School, Dalian (China)
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Abstract  
Objectives: To study the potential pathogenesis of endometriosis (EMs) in an area of estrogen receptors (ERs) and tyrosine kinase receptor type B (TrkB) expressions in tissues from patients with EMs. Study Design: The authors examined the expressions of ERα, ERβ, TrkB, brain-derived neurotrophic factor (BDNF), and SGPL1 in tissues with EMs, using real-time PCR, western blot, and immunohistochemistry. Results: ERα and SGPL1 were mainly expressed in eutopic endometrium than that in ectopic endometrium of patients with ovarian endometriosis (p < 0.05), while ERβ, BDNF, and TrkB were adverse, mainly detected in ectopic endometrium of the same patients with EMs (p < 0.01 and p < 0.05 ) by real-time PCR and western blot. ERβ, ERα, TrkB, and SGPL1 proteins were mainly expressed in eutopic endometrium of proliferative phase with EMs than that in eutopic endometrium of secretory phase (p < 0.05 ). TrkB, BDNF, and SGPL1 were not found in endometrium of proliferative or secretory phase in control group. Conclusions: ERβ expressed in cytoplasm may mediate pathogenesis of EMs.
Key words:  Endometriosis (EMs)      Estrogen receptor-α      (ERα)      Estrogen receptor-β      (ERβ)      Tyrosine kinase receptor B (TrkB)      Brainderived neurotrophic factor (BDNF)      Immunohistochemistry (IHC)     
Published:  10 February 2016     
*Corresponding Author(s):  X. YU     E-mail:  yuxiaohui369@163.com

Cite this article: 

X. Yu, H. Ren, T. Liu, M. Yong, H. Zhong. Expression and significance of ERβ and TrkB in endometriosis. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(1): 75-81.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog2027.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I1/75

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