Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2015, Vol. 42 Issue (6): 801-804    DOI: 10.12891/ceog2009.2015
Original Research Previous articles | Next articles
Interleukin-6 and C-reactive protein levels in the amniotic fluid as indicators of preterm delivery in Turkish women
M. Öz1, *(), B. Polat1, E. Özgü1, K. D. Seçkin1, C. Taşin1, N. Danişman1
1Zekai Tahir Burak Women’s Health Hospital, Ankara (Turkey)
Download:  PDF(93KB)  ( 6 )
Export:  BibTeX | EndNote (RIS)      
Abstract  
Objective: The aim of this study was to determine the value of amniotic fluid interleukin-6 (IL-6) and C-reactive protein (CRP) levels in the prediction of preterm delivery in singleton pregnancies without any known risk factors for preterm delivery in Turkish women. Materials and Methods: Patients in the present perinatology department who underwent mid-trimester genetic amniocentesis due to evidence of increased risk of aneuploidy in their prenatal serum screening tests were included in the study. A sample of amniotic fluid from each patient was assessed for IL-6 and CRP. Concentrations of IL-6 and CRP in the amniotic fluid of preterm delivery and term delivery groups were compared. Results: Of 151 singleton pregnancies, 142 participants were included in the study. The participants were assigned to either the preterm or term delivery group based on pregnancy outcome. IL-6 levels in the amniotic fluid were significantly higher in the preterm delivery group, and there was a statistically significant negative correlation between IL-6 concentrations in the amniotic fluid and gestational age at delivery (correlation coefficient (CC): -18.5%, p < 0.05). A negative correlation was also detected between CRP levels in the amniotic fluid and gestational age at delivery, but the correlation was not statistically significant (p = 0.068). Conclusion: Measuring IL-6 in the amniotic fluid can identify women at risk of preterm delivery. Because it is not acceptable to perform amniocentesis for this screening, it is more convenient for patients in whom genetic amniocentesis is performed.
Key words:  Preterm delivery      Interleukine-6      C-reactive protein      Midtrimester amniocentesis     
Published:  10 December 2015     
*Corresponding Author(s):  M. ÖZ     E-mail:  ozmurat@gmail.com

Cite this article: 

M. Öz, B. Polat, E. Özgü, K. D. Seçkin, C. Taşin, N. Danişman. Interleukin-6 and C-reactive protein levels in the amniotic fluid as indicators of preterm delivery in Turkish women. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(6): 801-804.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog2009.2015     OR     https://ceog.imrpress.com/EN/Y2015/V42/I6/801

[1] N. Dropińska, K. Chmaj-Wierzchowska, M. Wojciechowska, M. Wilczak. What is the state of knowledge on preterm birth?[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 505-510.
[2] A. E. Kholeif, M. Y. Khamis, S. Eltabakh, R. S. Swilam, A. Elhabashy, R. EISherif. Prediction of severity of preeclampsia in Egyptian patients: role of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and C-reactive protein[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 183-188.
[3] C. Chollet, B. Andre, M. Voglimacci, A. Ghassani, O. Parant, P. Guerby. Perinatal outcomes of second trimester antenatal genital bleeding[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 105-110.
[4] R. Csorba, P. Tsikouras, A. Bothou, S. Zervoudis, G. Iatrakis, X. Anthoulaki, D. Deuteraiou, A. Chalkidou, G. F. von Tempelhoff. Air travel during pregnancy: an update review and practical recommendation[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 862-866.
[5] Xianhu Fu, Xiaobo He, Daifei Sun, Qihui Fan, Bailei Zhang, Qian Wang, Yinfen Wang, Huili Chen. Histological chorioamnionitis could be predicted with high accuracy in preterm labor with intact membranes before delivery[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 720-724.
[6] E. Djakovic, S. Rakic. Depression, anxiety, and stress after preterm delivery: role of previous progesterone therapy[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 214-217.
[7] H. Alchalabi, Y.S. Khader, I. Lataifeh, B. Obeidat, F. Zayed, W. Khriesat, N. Obeidat. Morbidly adherent placenta previa: clinical course and risk from emergency delivery in a series of 26 women that underwent hysterectomy[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 524-527.
[8] J.L. Reed, E.E. Winger. IVIg therapy increases delivery birthweight in babies born to women with elevated preconception proportion of peripheral blood (CD56+/CD3-) natural killer cells[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(3): 384-391.
[9] Kwan Young Oh, Chan Hee Jin, Yong Hak Sohn, Hyun A. Cho, Moran Ki. The prevalence of abnormal vaginal flora and predictive factors for intrauterine infection in pregnant Korean women with preterm labor[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(3): 429-433.
[10] K.P. Fuller, S. DeGroff, A.F. Borgida. Neonatal outcomes based on antenatal corticosteroid exposure time for infants delivered between 23 and 34 weeks gestation[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(2): 247-251.
[11] S. Nergiz Avcioğlu, S.Ö. Altinkaya, S. Demi̇rcan Sezer, İ.K. Ömürlü, M. Küçük, H. Yüksel. Predictive value of procalcitonin and IL-6 versus cervical length for the admission-to-delivery interval in preterm labour[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(1): 39-43.
[12] M. Hadži-Lega, A. Daneva Markova, M. Stefanovic, M. Tanturovski. Combination of selected biochemical markers and cervical length in the prediction of impending preterm delivery in symptomatic patients[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(1): 154-160.
[13] J. Sun, S. Qu, C. Zhang, Z. Xiang, Z. Fu, L. Yao. Neonatal mortality rate and risk factors in northeast China: analysis of 5,277 neonates in 2005[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(5): 512-516.
[14] B. Liu, L. Zhang, R.W. Guo, W.J. Wang, X.Q. Duan, Y.W. Liu. The serum level of C-reactive protein in patients undergoing GnRH agonist protocols for in vitro fertilization cycle[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(2): 190-194.
[15] T.S. Patrelli, S. Gizzo, M. Plebani, D. Basso, G. Capobianco, C. Bartolucci, A. Bacchi Modena, M. Rondinelli, G.B. Nardelli. The trend of VEGF-A and PlGF in pregnant patients: a perspective case-control study on 214 women[J]. Clinical and Experimental Obstetrics & Gynecology, 2012, 39(1): 57-64.
No Suggested Reading articles found!