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Clinical and Experimental Obstetrics & Gynecology  2015, Vol. 42 Issue (6): 739-742    DOI: 10.12891/ceog2006.2015
Original Research Previous articles | Next articles
Analysis of the use of cyclosporin A to treat refractory immune recurrent spontaneous abortion
J. H. Fu1, *()
1Department of Obstetrics, Shandong Weifang People's Hospital, Weifang (China)
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Abstract  
Purpose: This study aims to determine the curative effect of cyclosporin A (CsA) in treating refractory immune recurrent spontaneous abortion (RSA). Patients with recurrent abortion caused by dysimmunity were enrolled. Materials and Methods: The patients were given aspirin, prednisone, heparin, immunotherapy with their husband’s leukomonocyte, and intravenous immunoglobulin (IVIG) treatment, but treatment outcomes were unsuccessful. Therefore, CsA was added to treat the women before and after pregnancy. During treatment, CsA concentration was maintained at 80 ng/ml to 150 ng/ml. The clinical effect and pregnancy outcome were observed. Results: Of the 26 patients, 20 cooperated and accomplished complete pregnancy. Twelve cases showed hypertensive disorders during pregnancy but did not exhibit symptoms of preeclampsia. Three cases were lost to follow-up. The success rate was 76.92%. Twenty patients underwent premature labor (34 weeks to 37 weeks). Nevertheless, the mothers and their children were all healthy. Conclusion: An appropriate dose of CsA has good curative effects and pregnancy results in the treatment of RSA.
Key words:  Cyclosporine      Recurrent spontaneous abortion      Pregnancy     
Published:  10 December 2015     
*Corresponding Author(s):  J. H. FU     E-mail:  fujinhuacn@163.com

Cite this article: 

J. H. Fu. Analysis of the use of cyclosporin A to treat refractory immune recurrent spontaneous abortion. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(6): 739-742.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog2006.2015     OR     https://ceog.imrpress.com/EN/Y2015/V42/I6/739

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