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Clinical and Experimental Obstetrics & Gynecology  2015, Vol. 42 Issue (4): 429-430    DOI: 10.12891/ceog1966.2015
Original Research Previous articles | Next articles
Improved implantation and live delivered pregnancy rates following transfer of embryos derived from donor oocytes by single injection of leuprolide in mid-luteal phase
J.H. Check1, 2, *(), C. Wilson2, K. Levine2, R. Cohen3, D. Corley1, 2
1Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ
2Cooper Institute for Reproductive Hormonal Disorders, P.C. Marlton, NJ
3Philadelphia College of Osteopathic Medicine, Department of Obstetrics and Gynecology, Philadelphia, PA (USA)
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Abstract  
Purpose: To determine if the use of a single injection of one-mg leuprolide acetate in mid-luteal phase can increase pregnancy rates in donor oocyte recipients. Materials and Methods: Prospective study where couples were made aware of a study using the gonadotropin releasing hormone agonist (GnRHa) triptorelin that in the mid-luteal phase found improved pregnancy rates following embryo transfer in donor oocyte recipients. They were given the option of a single one-mg injection of the GnRHa leuprolide acetate. Pregnancy outcome was compared according to whether leuprolide was given or not. Also compared were the average first serum beta-hCG level in those who conceived according to taking leuprolide or not. Results: Chi-square analysis showed a significantly higher clinical and live delivered pregnancy rate (63.9% and 52.8%) in those supplementing with leuprolide than those who did not (39.5% and 32.9%). Similarly implantation rates were significantly higher (44.2% vs. 25.2%). The average first serum beta-hCG level for those conceiving and taking leuprolide was 294 mIU/mL vs. 325 mIU/mL for those who did not. Conclusions: Similar to triptorelin the mid-luteal injection of leuprolide acetate improves pregnancy outcome in donor oocyte recipients.
Key words:  Donor oocyte recipients      Luteal phase      Leuprolide acetate      Embryo implantation     
Published:  10 August 2015     
*Corresponding Author(s):  J.H. CHECK     E-mail:  laurie@ccivf.com

Cite this article: 

J.H. Check, C. Wilson, K. Levine, R. Cohen, D. Corley. Improved implantation and live delivered pregnancy rates following transfer of embryos derived from donor oocytes by single injection of leuprolide in mid-luteal phase. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(4): 429-430.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog1966.2015     OR     https://ceog.imrpress.com/EN/Y2015/V42/I4/429

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