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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (5): 721-725    DOI: 10.12891/ceog1957.2017
Original Research Previous articles | Next articles
What is the best initial cycle IVF protocol for patients over 35 years old?
P. Telli Celtemen1, *(), N. Bozkurt1, M. Erdem1, M.B. Celtemen2, A. Erdem1, M. Öktem1, R.O. Karabacak1
1 Gazi University Department of Obstetrics and Gynecology, Ankara, Turkey
2 Cankiri Government Hospital, Department of Obstetrics and Gynecology Cankiri, Turkey
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Abstract  
Purpose: The aim of this study was to find the most effective ovarian hyperstimulation protocol for patients over 35 years old. Materials and Methods: This is a retrospective study of 390 first IVF cycles of patients older than 35 years, that had serum follicle stimulating hormone < 10 IU/L, and that had no co-existing endocrine disorders. Long (n=181), antagonist (n=71), and micro-dose flare-up (n=138) protocols were evaluated. Results: Clinical pregnancy and live birth rates were highest in long protocol group and lowest in micro-dose protocol group. The difference between long and micro-dose protocol groups was statistically significant (p < 0.05). In multivariate logistic regression analysis, picked-up oocyte count (p = 0.005), endometrium thickness at hCG day (p = 0.006), age (p = 0.006), and antral follicle numbers (p = 0.013) were found to be predictive for obtaining clinical pregnancy. Treatment protocols were not found to be predictive for obtaining clinical pregnancy (p > 0.05). Conclusion: Treatment protocols were not found to be predictive for obtaining clinical pregnancy. Patient’s age, antral follicle number, endometrial thickness at hCG day, and picked-up oocyte counts directly effect the pregnancy rates. Long protocol affects these factors positively can be preferred in younger patients with higher antral follicle numbers.
Key words:  IVF hyperstimulation protocol      IVF outcome      Advanced age     
Published:  10 October 2017     
*Corresponding Author(s):  P. TELLI CELTEMEN     E-mail:  pinartelli@gmail.com

Cite this article: 

P. Telli Celtemen, N. Bozkurt, M. Erdem, M.B. Celtemen, A. Erdem, M. Öktem, R.O. Karabacak. What is the best initial cycle IVF protocol for patients over 35 years old?. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(5): 721-725.

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https://ceog.imrpress.com/EN/10.12891/ceog1957.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I5/721

[1] M.B. Celtemen, P. Telli Celtemen, N. Bozkurt, C. Karakaya, S. Elberg, R.H. Gursoy. Follicular fluid anti-Müllerian hormone, inhibin-A, progesterone, and estradiol level differences in patients under controlled ovarian stimulation[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 166-169.
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