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Clinical and Experimental Obstetrics & Gynecology  2015, Vol. 42 Issue (4): 473-479    DOI: 10.12891/ceog1873.2015
Original Research Previous articles | Next articles
Serum levels of the adipokines, free fatty acids, and oxidative stress markers in obese and non-obese preeclamptic patients
A. Turgut1, *(), A. Ozler1, N.Y. Goruk1, S.Y. Tunç1, M.E. Sak1, M.S. Evsen1, O. Evliyaoglu2, T. Gul1
1Department of Obstetrics and Gynaecology, Dicle University School of Medicine, Diyarbakir
2Department of Biochemistry, Dicle University School of Medicine, Diyarbakir (Turkey)
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Abstract  
Purpose of investigation: To investigate the roles of adipokines, free fatty acid (FFA), and oxidative stress in obese and non-obese preeclamptic patients. Materials and Methods: Gestational age-matched obese preeclamptic (n=32), non-obese preeclamptic (n=32) ,and non-obese normotensive healthy (n=32) pregnant women were included in the study. Serum insulin, insulin resistance, leptin, nesfatin, ghrelin, chemerin, FFA levels, total antioxidant status, total oxidant status, and oxidative stress index were determined. Results: Leptin and nesfatin levels were significantly lower and ghrelin levels were significantly higher in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptic groups. Chemerin and FFA levels were significantly higher in obese preeclamptics as compared to non-obese preeclamptics and normotensive group. Total antioxidant status (TAS) levels were significantly higher in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptics. Total oxidative status (TOS) and oxidative stress index (OSI) levels were significantly lower in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptics. Conclusion: Serum levels of adipokines, TOS, and FFAs were significantly higher in pregnants with preeclampsia as compared to non-obese normotensive controls. Chemerin and FFAlevels were significantly higher in obese preeclamptics as compared to non-obese preeclamptics.
Key words:  Preeclampsia      Obesity      Free fatty acid      Adipokines     
Published:  10 August 2015     
*Corresponding Author(s):  A. TURGUT     E-mail:  abdulkadirturgut@gmail.com

Cite this article: 

A. Turgut, A. Ozler, N.Y. Goruk, S.Y. Tunç, M.E. Sak, M.S. Evsen, O. Evliyaoglu, T. Gul. Serum levels of the adipokines, free fatty acids, and oxidative stress markers in obese and non-obese preeclamptic patients. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(4): 473-479.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog1873.2015     OR     https://ceog.imrpress.com/EN/Y2015/V42/I4/473

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