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Clinical and Experimental Obstetrics & Gynecology  2015, Vol. 42 Issue (3): 347-351    DOI: 10.12891/ceog1866.2015
Original Research Previous articles | Next articles
Novasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial
D. Athanatos1, *(), G. Pados1, C.A. Venetis1, P. Stamatopoulos1, D. Rousso2, D. Tsolakidis1, C.P. Stamatopoulos1, B.C. Tarlatzis1
11st Dept of Obstetrics and Gynecology, “Papageorgiou” University Hospital, Aristotle University of Thessaloniki, Thessaloniki
23rd Dept of Obstetrics and Gynecology, “Hippocration” University Hospital, Aristotle University of Thessaloniki, Thessaloniki (Greece)
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Abstract  
Purpose of investigation: To compare the efficacy and safety of two different second-generation ablation devices, Novasure impedance control system and microwave endometrial ablation (MEA), in cases of abnormal uterine bleeding (AUB). Materials and Methods: This is a randomized controlled trial that took place in a single Gynecological Department of a University Hospital. Sixty-six women with dysfunctional uterine bleeding (DUB), unresponsive to medical treatment, were included in the trial. The ratio of women allocated to bipolar radio-frequency ablation or MEA was 1:1. Follow-up assessments were carried out at three and 12 months post-ablation. The present main outcome measure was amenorrhea rates 12-months post-treatment. Results: The rate of amenorrhea at 12- months post-ablation was significantly higher in women treated by Novasure (25/33; 75.8%) as compared to those treated by MEA (8/33; 24.2%) (rate difference: +51.5%, 95% CI: +27.8 to +67.7). Conclusion: In women with DUB, endometrial ablation with Novasure bipolar radiofrequency impedance-controlled system is associated with increased rates of amenorrhea at 12-months post-treatment as compared to the MEA method.
Key words:  Abnormal uterine bleeding      Novasure      Microwave endometrial ablation     
Published:  10 June 2015     
*Corresponding Author(s):  D. ATHANATOS     E-mail:  dimitriosathanatos@hotmail.com

Cite this article: 

D. Athanatos, G. Pados, C.A. Venetis, P. Stamatopoulos, D. Rousso, D. Tsolakidis, C.P. Stamatopoulos, B.C. Tarlatzis. Novasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(3): 347-351.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog1866.2015     OR     https://ceog.imrpress.com/EN/Y2015/V42/I3/347

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