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Clinical and Experimental Obstetrics & Gynecology  2014, Vol. 41 Issue (5): 561-566    DOI: 10.12891/ceog17902014
Original Research Previous articles | Next articles
Expression of anti-inflammatory mediator lipoxin A4 and inflammation responsive transcriptive factors NF-kappa B in patients with preeclampsia
L.L. Huang1, S. Su1, , R. Awale1, , X.Y. Zhang1, L.L. Zhong1, H. Tang1, *()
1Department of Obstetrics and Gynecology, The First Affiliated Hospital of GuangXi Medical University, Nanning, GuangXi (China)
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Abstract  
Objective: To evaluate the role of lipoxin A4 (LXA4), NF-κB p65 in preeclampsia. Materials and Methods: LXA4 in blood serum and the lipoxin A4 receptor (ALX-R), NF-κB p65 mRNA, protein expressions in placenta-specific tissues were obtained from patients with preeclampsia and normal pregnancy. Results: Levels of lipoxin A4 in women with mild preeclampsia was significantly high (p < 0.05). There was no significant statistical difference between normal pregnancy and severe preeclampsia (p > 0.05). The mRNA expression of ALX-R was significantly low in women with preeclampsia than in control group (p < 0.01) and mRNA expression of NF-κB p65 was significantly high in preeclampsia (p < 0.01). The immunohistochemical staining of NF-κB p65 protein was stronger in severe preeclampsia group whereas staining of ALX-R in placental tissue was weaker than in control group (p < 0.01). ALX-R mRNA was negatively correlated with NF-κB (p < 0.0001), but there was no correlation between LXA4 and ALX-R mRNA. Conclusion: There was an excessive maternal inflammatory response in preeclampsia. LXA4, ALX-R, and NF-κB p65 may be involved in the disease process of preeclampsia.
Key words:  Preeclampsia      Lipoxin A4      Lipoxin A4 receptor      NF-κB p65      Inflammatory reaction     
Published:  10 October 2014     
*Corresponding Author(s):  H. TANG     E-mail:  2657316472@qq.com
About author:  These authors contributed equally.

Cite this article: 

L.L. Huang, S. Su, R. Awale, X.Y. Zhang, L.L. Zhong, H. Tang. Expression of anti-inflammatory mediator lipoxin A4 and inflammation responsive transcriptive factors NF-kappa B in patients with preeclampsia. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(5): 561-566.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog17902014     OR     https://ceog.imrpress.com/EN/Y2014/V41/I5/561

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