Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2015, Vol. 42 Issue (1): 62-66    DOI: 10.12891/ceog1789.2015
Original Research Previous articles | Next articles
Changes and clinical significance of peripheral blood helper T lymphocyte and natural killer (NK) cells in unexplained recurrent spontaneous abortion (URSA) patients after abortion and successful pregnancy
L.Y. Zhu1, X. Chen1, Z.Z. Xu1, L. Xu1, T. Mao2, H. Zhang1, *()
1Department of Obstetrics and Gynecology, the 2nd Affiliated Hospital of Soochow University, Suzhou
2Department of Clinical Laboratory, the 2nd Affiliated Hospital of Soochow University, Suzhou (China)
Download:  PDF(230KB)  ( 10 )
Export:  BibTeX | EndNote (RIS)      
Abstract  Objective: This study aims to investigate the number changes and the clinical significance of the peripheral blood T lymphocyte subsets and NK (natural killer) cells in unexplained recurrent spontaneous abortion (URSA) patients before and after abortion, as well as after successful pregnancy. Materials and Methods: Thirty-nine URSA patients (URSA-abortion group), among who 22 patients were followed up until the final successful parturition (URSA-pregnancy group), 31 normal-pregnancy (NP) cases and 25 normal non-pregnancy (NNP) control cases in which the peripheral blood T lymphocytes and subsets, B cells, and NK cells were assessed flow cytometry. Results: Compared with the URSA-pregnancy group and the NP group, the Th cells and NK cells of the URSA-abortion group increased (p < 0.05); compared with the NNP group, the total number of T cells decreased after the first, second, and third month of the URSA abortion (p < 0.05); Th cells decreased within one to six months of the URSA abortion (p < 0.05); proportion of NK cells was significantly higher in URSA patients (p < 0.05). Conclusion: The abnormal numbers of the peripheral blood T cell subsets and NK cells were related with the occurrence of URSA.
Key words:  Recurrent spontaneous abortion      Pregnancy      Helper T lymphocyte      NK cells     
Published:  10 February 2015     
*Corresponding Author(s):  H. Zhang     E-mail:  hongzhangdoc@126.com

Cite this article: 

L.Y. Zhu, X. Chen, Z.Z. Xu, L. Xu, T. Mao, H. Zhang. Changes and clinical significance of peripheral blood helper T lymphocyte and natural killer (NK) cells in unexplained recurrent spontaneous abortion (URSA) patients after abortion and successful pregnancy. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(1): 62-66.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog1789.2015     OR     https://ceog.imrpress.com/EN/Y2015/V42/I1/62

[1] Amanda M. Wang, Alan J. Lee, Shannon M. Clark. The effects of overweight and obesity on pregnancy-related morbidity[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 999-1009.
[2] Leen Van den Eeden, Greet Leysens,Dominique Mannaerts, Yves Jacquemyn. Air pollution: cardiovascular and other negative effects on pregnancy: a narrative review[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1010-1016.
[3] Xin Du, Qian Zou, Yu-Lan Liu. Transumbilical single-hole laparoscopic treatment of cesarean scar pregnancy by uterine artery pre-ligation: a report of 4 cases[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1044-1047.
[4] Marcelo Epsztein Kanczuk, Nicholas J Lightfoot, Alison Pighills, Antony Ji, Casey Steele, Daniel Bartlett. The time to perform spinal or general anaesthesia in COVID-19 positive parturients requiring emergency caesarean delivery: a prospective crossover simulation study[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1099-1106.
[5] Noor Hazim Abdulkareem, Elham Hazeim Abdulkareem. SARS-CoV-2 detection in pregnant and non-pregnant women[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1141-1145.
[6] Min Jung Kim, Hee-Sook Lim, Hae-Hyeog Lee, Tae-Hee Kim, Yongsoon Park. Dietary assessment, nutrition knowledge, and pregnancy outcome in high-risk pregnant Korean women[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1178-1185.
[7] Neha Sethi, Ann Gee Tan, Maherah Kamarudin, Sofiah Sulaiman. Successful delivery of a twin pregnancy with complete hydatidiform mole and coexistent live fetus: a case report and review of literature[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1232-1247.
[8] Luca Roncati, Greta Gianotti, Elisa Ambrogi, Giovanna Attolini. COVID-19 in pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 778-780.
[9] Silvia Amodeo, Giulia Bonavina, Anna Seidenari, Paolo Ivo Cavoretto, Antonio Farina. Real-world implementation and adaptation to local settings of first trimester preeclampsia screening in Italy: a systematic review[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 812-819.
[10] Yu Deng, Zhan-Hui Ou, Min-Na Yin, Pei-Ling Liang, Zhi-Heng Chen, Abraham Morse, Ling Sun. Age and anti-Műllerian hormone: prediction of cumulative pregnancy outcome in in vitro fertilization with diminished ovarian reserve[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 835-841.
[11] Serdar Balci. The effect of ultraviolet index measurements on levels of vitamin D andinflammatory markers in pregnant women[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 888-892.
[12] Anna M. Rubinshtein, Oleg V. Golyanovskiy. Obstetric outcomes in women of advanced maternal age after assisted reproduction[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 893-900.
[13] Qian Hu, Mohammed Sharooq Paramboor, Tao Guo. Diagnosis and management of intramural ectopic pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 974-979.
[14] Ovadya Rosenbluh, Asnat Walfisch. Birth defects associated with obesity[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 472-477.
[15] Sara Oday, Maysoon Sharief. The role of salivary progesterone and cervical length measurement in predicting risk of spontaneous preterm birth[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 509-513.
No Suggested Reading articles found!