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Clinical and Experimental Obstetrics & Gynecology  2014, Vol. 41 Issue (2): 205-207    DOI: 10.12891/ceog17642014
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Pregnancy management in Behcet’s disease treated with uninterrupted infliximab. Report of a case with fetal growth restriction and mini-review of the literature
G. Mainini1, *(), M.C. Di Donna1, E. Esposito1, S. Ercolano1, R. Correa1, L. Stradella2, A. Della Gala2, P. De Franciscis2
1Department of Gynaecology and Obstetrics, S. Leonardo Hospital, Castellammare di Stabia, Naples
2Department of Woman, Child and of General and Specialized Surgery, Second University of Studies of Naples, Naples (Italy)
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Abstract  
Background: The mutual impact of Behcet’s disease (BD) and pregnancy is variable and still unclear. Among the safe drugs administered, the newer infliximab (IFX) was rarely experienced in pregnancy, particularly in the third trimester. Case: The authors report a pregnancy with fetal growth restriction at 36 weeks in a 31-year-old primigravida with symptomatic BD, treated with uninterrupted monthly IFX and daily enoxaparin. The patient was induced at 38 weeks and had an uneventful vaginal delivery of a healthy baby. The postpartum period and following six months were uneventful for mother in terms of BD exacerbation, and newborn in terms of potential risks of neonatal BD and/or infections due to late immunosuppressive IFX administration. Conclusion: Because of the inconstant mutual impact, BD pregnancies should be precautionary considered at “potential high-risk” and need a careful and close monitoring by a multidisciplinary team with specific expertise.
Key words:  Behcet’s disease      Vasculitis      Infliximab      Pregnancy      Obstetric outcome      Fetal growth restriction     
Published:  10 April 2014     
*Corresponding Author(s):  G. MAININI     E-mail:  giampaolomainini@libero.it

Cite this article: 

G. Mainini, M.C. Di Donna, E. Esposito, S. Ercolano, R. Correa, L. Stradella, A. Della Gala, P. De Franciscis. Pregnancy management in Behcet’s disease treated with uninterrupted infliximab. Report of a case with fetal growth restriction and mini-review of the literature. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(2): 205-207.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog17642014     OR     https://ceog.imrpress.com/EN/Y2014/V41/I2/205

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