Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2015, Vol. 42 Issue (3): 295-299    DOI: 10.12891/ceog1756.2015
Original Research Previous articles | Next articles
Effects of estrogen intervention on the biomechanical characteristics of serum SOD, MDA, and middle cerebral artery in aged female rats
S.J. Wang1, S.J. Zhao1, Y.S. Wang1, T. Yu2, *(), M. Luo2
1Department of Critical Care Medicine, the 1st Hospital of Jilin University, Changchun
2Department of Osteology, Sino-Japanese Friendship Hospital of Jilin University, Changchun (China)
Download:  PDF(170KB)  ( 23 )
Export:  BibTeX | EndNote (RIS)      
Abstract  
Objective: This study aims to study the biological and biomechanical characteristics of the middle cerebral artery (MCA) in aged and estrogen-intervened aged rats, thereby providing biomechanical basis for clinics. Materials and Methods: Thirty 18-month-old Sprague Dawley (SD) rats, 30 18-month-old estrogen-intervened SD rats, and 30 four-month-old SD rats were studied. The estrogen-intervened rats were given estradiol benzoate on the fifth feeding day. Thirty-four days after the feeding, the serum of each rat was obtained. The radioimmunoassay was performed for the content determination of serum E2, ER, malondialdehyde (MDA), and superoxide dismutase (SOD). The tensile test was performed to evaluate the MCA of each rat. Results: Through the estrogen intervention, the serum contents of E2, ER, SOD, and MDA in old rats were restored to normal levels. The maximum stress, maximum strain, and elastic limit of the MCA in the aged estrogen- intervened rat group were greater than those of the non-intervened aged rat group, with a significant difference (p < 0.05). The elastic modulus in the aged estrogen-intervened rat group was less than that of the non-intervened aged rat group, with a significant difference (p < 0.05). Conclusion: E2 intervention can improve the flexibility, toughness, and compliance of MCA in aged rats.
Key words:  Aged female rat      Estrogen      Middle cerebral artery      Mechanical properties     
Published:  10 June 2015     
*Corresponding Author(s):  T. YU     E-mail:  taoyucn@126.com

Cite this article: 

S.J. Wang, S.J. Zhao, Y.S. Wang, T. Yu, M. Luo. Effects of estrogen intervention on the biomechanical characteristics of serum SOD, MDA, and middle cerebral artery in aged female rats. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(3): 295-299.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog1756.2015     OR     https://ceog.imrpress.com/EN/Y2015/V42/I3/295

[1] Duygu Adıyaman, Bahar Konuralp Atakul, Melda Kuyucu, Hakan Gölbasi, Atalay Ekin. Difference between near-field and far-field of middle cerebral artery doppler pulsatility index and peak systolic velocity: a prospective study[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 66-72.
[2] J.H. Check, A. DiAntonio, D.L. Check, M.P. Dougherty, G. Diantonio. A study to determine if estrogen (E) is needed to induce de novo progesterone (P) receptors on gamma/delta t cells as evidenced by determining the degree of rise of progesterone induced blocking factor (PIBF) following P exposure in males[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(3): 419-420.
[3] Y. Zheng, G. Niu, H. Zhang, W. Lu, Z. Liu. Estrogen replacement therapy is not a recommended therapy for postmenopausal women with coronary heart disease: a meta-analysis[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 219-226.
[4] O.S. Kerimoglu, A. Pekin, S.A. Yılmaz, F.N. İncesu, S. Nergiz, N.U. Doğan, H. Acar, C. Celik. Effect of the FSH receptor polymorphism on the age at menarche[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 241-244.
[5] A. Genç, E. Tutkun, D. Güven, H. Acar. Investigation of the endometrial thickness and estrogen level in athletes and sedentaries[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 123-126.
[6] P. Marcos-Figueiredo, D. Ferreira, C. Ferreira, E. Pereira, M. Branco. Fetal anaemia: two clinical cases with fetal blood transfusion[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 164-167.
[7] J.H. Check, R. Cohen. Amelioration of severe generalized idiopathic pruritus in an estrogen deficient woman taking an aromatase inhibitor for breast cancer following treatment with amphetamine salts[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(6): 934-935.
[8] E. Ricci, F. Chiaffarino, S. Cipriani, R. Cioffi, P. Viganò, E. Garavaglia, F. Parazzini. Wine, spirits, and beer intake and endometriosis risk among infertile women: results from a case control study[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 548-551.
[9] X. Yu, H. Ren, T. Liu, M. Yong, H. Zhong. Expression and significance of ERβ and TrkB in endometriosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(1): 75-81.
[10] J. Awwad, C. Farra, A. Hannoun, M. Abou-Abdallah, K. Isaacson, G. Ghazeeri. Idiopathic premature ovarian failure: what is the most suitable ovarian stimulation protocol?[J]. Clinical and Experimental Obstetrics & Gynecology, 2013, 40(3): 327-330.
[11] G. Mainini, M. Torella, M.C. Di Donna, E. Esposito, S. Ercolano, R. Correa, G. Cucinella, L. Stradella, A. Luisi, A. Basso, F.V. Cerreto, R. Cicatiello, M. Matteo, P. De Franciscis. Nonhormonal management of postmenopausal women: effects of a red clover based isoflavones supplementation on climacteric syndrome and cardiovascular risk serum profile[J]. Clinical and Experimental Obstetrics & Gynecology, 2013, 40(3): 337-341.
[12] D.M. Rodrigues-Junior, P.V. Lopes-Costa, A.R. dos Santos, B.B. da Silva. Effects of tamoxifen and raloxifene on body and uterine weights of rats in persistent estrus[J]. Clinical and Experimental Obstetrics & Gynecology, 2012, 39(3): 362-364.
[13] J. Wang, X. Ma. Effects of estrogen and progestin on expression of MMP-2 and TIMP-2 in a nude mouse model of endometriosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2012, 39(2): 229-233.
[14] H. Meden-Vrtovec, K. Gersak, D. Franic. Distribution of etiological factors of hypergonadotropic amenorrhea[J]. Clinical and Experimental Obstetrics & Gynecology, 2011, 38(4): 369-372.
[15] A.C.S. Chuery, N.M. de Gois Speck, K.F.Q. de Moura, P.N. Belfort, C. Sakano, J.C.L. Ribalta. Efficacy of vaginal use of topical estriol in postmenopausal women with urogenital atrophy[J]. Clinical and Experimental Obstetrics & Gynecology, 2011, 38(2): 143-145.
No Suggested Reading articles found!