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Clinical and Experimental Obstetrics & Gynecology  2015, Vol. 42 Issue (2): 168-172    DOI: 10.12891/ceog1747.2015
Original Research Previous articles | Next articles
Genetic variation in COX-2 -1195 and the risk of endometriosis and adenomyosis
Y. Wang1, Y. Qu2, W. Song3
1Department of Obstetrics and Gynecology, Tangshan Worker’s Hospital, Tangshan Hebei
2Department of Histology and Embryology, Basic Medical College of Hebei United University, Tangshan Hebei
3Department of Radiotherapy and Chemotherapy, Tangshan Worker’s Hospital, Tangshan Hebei (China)
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Abstract  
Aim: This study aims to explore the relationship between COX-2 gene polymorphism and the hereditary susceptibility of endometriosisand adenomyosis. Materials and Methods: Gene polymorphism in COX-2 gene was genotyped in 170 cases of endometriosis, 150 cases of adenomyosis, and 240 matched non-endometriosis and non-adenomyosis controls. Results: Genotypic frequencies of GG, AG, and AA in COX-2 locus in endometriosis and adenomyosis were 16.5%, 51.2%, 32.4% and 16.0%, 49.3%, 34.7%, respectively. They were bothsignificantly different from those in the control group (24.6%, 53.3%, and 22.1%) (p < 0.05). An allele frequency in endometriosis andadenomyosis were significantly higher than that in the control group. The risk of endometriosis or adenomyosis for those carrying two Aalleles were 2.19 and 2.41 times to non-A genotype. Conclusion: Genetic variation of G to A at -1195 locus in the promoter region of COX-2 gene increases the risk of endometriosis and adenomyosis, and the genetic susceptibility of these two diseases are similar.
Key words:  Endometriosis      Adenomyosis      COX-2      genetic susceptibility      Single nucleotide polymorphisms (SNPs)     
Published:  10 April 2015     
*Corresponding Author(s):  W. Song     E-mail:  wenguangsongcn@126.com

Cite this article: 

Y. Wang, Y. Qu, W. Song. Genetic variation in COX-2 -1195 and the risk of endometriosis and adenomyosis. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(2): 168-172.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog1747.2015     OR     https://ceog.imrpress.com/EN/Y2015/V42/I2/168

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