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Clinical and Experimental Obstetrics & Gynecology  2014, Vol. 41 Issue (6): 691-693    DOI: 10.12891/ceog17402014
Original Research Previous articles | Next articles
Elevated tissue levels of tumor necrosis factor-α in vulvar vestibulitis syndrome
E. Seckin-Alac1, S.E. Akhan1, E. Bastu1, *(), S. Tuzlalik2, E. Yavuz2
1Department of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul
2Department of Pathology, Istanbul University School of Medicine, Istanbul (Turkey)
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Abstract  
The purpose of this study was to compare levels of inflammatory cytokines, namely TNF- α, IL-1%, and IL-1 receptor in women with vulvar vestibulitis syndrome (VVS) relative to levels in controls. The authors hypothesized that tissue concentrations of inflammatory cytokines would be elevated significantly in women with VVB compared to pain-free controls. The study population consisted of 15 women with strictly defined VVB in reproductive age and 13 age-matched women with no history of vulvodynia. For TNF-α, positive staining was observed in 40% of the samples from the study group and in 7.7% of the samples from the control group. The difference between the groups was statistically significant (p < 0.05). In conclusion, a limitation of the present study was the relatively small sample size. However, the authors’ intention was simply to propose that the local inflammation may be mediated by cytokines as TNF-α may rather than trying to single out a pathogenesis of VVS. The authors’ findings of elevated TNF-α may suggest new therapeutic alternatives for VVS, as inhibiting cytokine synthesis or antagonism of the cytokine receptor.
Key words:  TNF- α      IL-1%      IL-1 receptor      Vulvar vestibulitis syndrome     
Published:  10 December 2014     
*Corresponding Author(s):  E. BASTU     E-mail:  ercan.bastu@istanbul.edu.tr

Cite this article: 

E. Seckin-Alac, S.E. Akhan, E. Bastu, S. Tuzlalik, E. Yavuz. Elevated tissue levels of tumor necrosis factor-α in vulvar vestibulitis syndrome. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(6): 691-693.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog17402014     OR     https://ceog.imrpress.com/EN/Y2014/V41/I6/691

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