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Clinical and Experimental Obstetrics & Gynecology  2014, Vol. 41 Issue (5): 517-520    DOI: 10.12891/ceog17372014
Original Research Previous articles | Next articles
Normal “high” thyroid stimulating hormone (TSH) levels and pregnancy rates in patients undergoing IVF with donor eggs
L.H. Sordia-Hernandez1, *(), A. Morales Martinez1, J.M. Gris2, J. Herrero2, C. Hernandez Uzcanga1, M. Merino1, O. Valdes1, G. Guerrero Gonzalez1
1University Center of Reproductive Medicine, Hospital Universitario of the Universidad Autonoma de Nuevo Leon in Monterrey, Monterrey (Mexico)
2Servicio de Ginecología Hospital Vall d`Hebron, Universitat Autonoma de Barcelona in Barcelona (Spain)
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Abstract  
Objective: To determine if a relationship exists between pregnancy rates obtained in patients undergoing in vitro fertilization (IVF) with donor eggs and levels of thyroid stimulating hormone greater than 2.5 mIU/L but still within a range considered normal. Study design: Retrospective comparative cohort study. With prior approval of the Ethics Committee, 233 patients undergoing IVF with donor eggs, in a two-year period, were included. Patients were grouped depending on the thyroid stimulating hormone (TSH) level. Pregnancy rates were compared. Statistical analysis was made with the Chi-square test. Results: Pregnancy rates, depending on the TSH level, were 56.6% in patients with TSH levels below 2.49 mU/L vs. 21.6%, in patients with levels above 2.5 mU/L. This difference was statistically significant (p < 0.001). Conclusions: Mild abnormalities of thyroid function may adversely affect the pregnancy rates in patients undergoing in vitro fertilization with donor eggs. A possible alteration in endometrial function may be associated.
Key words:  Thyroid stimulating hormone      In vitro fertilization (IVF)      Egg donation      Clinical pregnancy rates     
Published:  10 October 2014     
*Corresponding Author(s):  L.H. SORDIA HERNANDEZ     E-mail:  luissordia@telmexmail.com

Cite this article: 

L.H. Sordia-Hernandez, A. Morales Martinez, J.M. Gris, J. Herrero, C. Hernandez Uzcanga, M. Merino, O. Valdes, G. Guerrero Gonzalez. Normal “high” thyroid stimulating hormone (TSH) levels and pregnancy rates in patients undergoing IVF with donor eggs. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(5): 517-520.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog17372014     OR     https://ceog.imrpress.com/EN/Y2014/V41/I5/517

[1] N. Al-Husban, A. Hababeh, M. Al-Kasasbeh, R. Odeh, M. Shaheen, D. Moughrabi, D. Zabalawi. Thyroid stimulating hormone (TSH) level variations in early pregnancy and feto-maternal outcome; retrospective study[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 675-680.
[2] W.X. Chen, L.Y. Tang. Relationship between subclinical hypothyroidism during pregnancy and hypertensive disorder complicating pregnancy and its poor prognosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 111-116.
[3] A. Samsami, A. Zarei, S. Shahrivar. Effects of estradiol injection on outcome of in-vitro fertilization: a randomized, double-blind, placebo controlled trial[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(6): 875-879.
[4] T. Kalampokas, C. Sofoudis, I. Boutas, L. Aravantinos, E. Kalampokas, E. Deligeoroglou. IVF/ICSI frozen replacement cycles; every cycle? Opinion expressed after a systematic review of the literature[J]. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(2): 173-175.
[5] B. Ma, Y. Wang, H. Zhang, X. Zhang. A study comparing three different laser-assisted hatching techniques[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(1): 37-40.
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