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Clinical and Experimental Obstetrics & Gynecology  2014, Vol. 41 Issue (2): 174-176    DOI: 10.12891/ceog16132014
Original Research Previous articles | Next articles
Alteration of T-cell subpopulations and lipid peroxidation in the blood of patients with vulvar non-neoplastic epithelial disorder
G.T. Li1, S.Z. Guo2, *(), Y.J. Liu1, B. Yang1
1Department of Obstetrics and Gynecolgy, China Meitan General Hospital, Chaoyang District, Beijing
2Department of Pathology, Capital Medical University, You An Men, Beijing (China)
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Abstract  
Objective: To determine the relationship between vulvar non-neoplastic epithelial disorder and thymus-dependent lymphyocyte levels and lipid peroxidation. Materials and Methods: the authors measured the levels of CD3+, CD4+, CD8+, CD16+ T cell, and the concentration of superoxide dismutase (SOD) and malondialdehyde (MDA) in the blood of 62 patients with vulvar non-neoplastic epithelial disorder. A control group consisted of 30 normal women from the present hospitals. Results: The level of CD4+/CD8+ T-lymphocytes and SOD in the blood of the patients with vulvar non-neoplastic epithelial disorder was significantly lower than that in control subjects, but the level of MDA was higher as compared with normal women. Conclusion: There is increased immune activation and lipid peroxidation in patients with vulvar non-neoplastic epithelial disorder, which could contribute to destruction of vulvar tissue.
Key words:  Vulvar non-neoplastic epithelial disorder      Thymus-dependent lymphyocyte      Lipid peroxidation      Superoxide dismutase     
Published:  10 April 2014     
*Corresponding Author(s):  lgt93@126.com; sinocin@sina.com (S.Z. GUO)   

Cite this article: 

G.T. Li, S.Z. Guo, Y.J. Liu, B. Yang. Alteration of T-cell subpopulations and lipid peroxidation in the blood of patients with vulvar non-neoplastic epithelial disorder. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(2): 174-176.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog16132014     OR     https://ceog.imrpress.com/EN/Y2014/V41/I2/174

[1] S.B. Patil, M.V. Kodliwadmath, S.M. Kodliwadmath. Lipid peroxidation and antioxidant activity in complicated pregnancies[J]. Clinical and Experimental Obstetrics & Gynecology, 2009, 36(2): 110-112.
[2] S. B. Patil, M. V. Kodliwadmath, S. M. Kodliwadmath. Lipid peroxidation and antioxidant status in hypertensive pregnancies[J]. Clinical and Experimental Obstetrics & Gynecology, 2008, 35(4): 275-278.
[3] S. B. Patil, M. V. Kodliwadmath, S. M. Kodliwadmath. Role of lipid peroxidation and enzymatic antioxidants in pregnancy-induced hypertension[J]. Clinical and Experimental Obstetrics & Gynecology, 2007, 34(4): 239-241.
[4] G. Bayhan, Y. Atamer, A. Atamer, B. Yokus, Y. Baylan. Significance of changes in lipid peroxides and antioxidant enzyme activities in pregnant women with preeclampsia and eclampsia[J]. Clinical and Experimental Obstetrics & Gynecology, 2000, 27(2): 142-146.
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