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Clinical and Experimental Obstetrics & Gynecology  2014, Vol. 41 Issue (2): 149-153    DOI: 10.12891/ceog15802014
Original Research Previous articles | Next articles
Implications of premature ovarian failure on bone turnover markers and bone mineral density
N. Kurtoglu-Aksoy1, S.E. Akhan1, E. Bastu1, *(), F. Gungor-Ugurlucan1, A. Telci2, A.C. Iyibozkurt1, S. Topuz1
1Department of Obstetrics and Gynecology
2Department of Biochemistry, Istanbul University School of Medicine, Istanbul (Turkey)
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Abstract  
Introduction: Premature ovarian failure (POF) is the cessation of ovarian function before the age of 40. The loss of ovarian function, whether premature or not, has an overwhelming impact on female skeletal health, leading to an increased risk of developing osteoporosis because of the lengthened time of exposure to reduced estrogen. The objective of this study was to compare the implications of premature ovarian failure on bone turnover markers and bone mineral density in patients under the age of 40. Materials and Methods: Sixty-one patients with a diagnosis of POF were selected for this prospective study. Patients were divided into two groups according to age, patients < 30 years old (n = 30), and patients ≥ 30 years old (n = 31). Results: Between the two age sub-groups (< 30 and ≥ 30 years old), there was a significant difference in menopause rating scale (MRS), lumbar spine t-score, N-telopeptides crosslinks (NTx), and serum bone specific alkaline phosphatase (bALP) between the two age groups (10.93 ± 7.79 vs 17.38 ± 8.62; -1.84 ± 1.47 vs -1.06 ± 0.93; 58.80 ± 21.32 vs 41.1 ± 11.37; 48.99 ± 42.16 vs 23.76 ± 10.08, respectively). Conclusion: It is apparent that bone mineral density (BMD) is commonly less in women with POF than normal healthy women. Therefore, measurement of BMD is warranted. At this time, it is not clear how often the tests should be carried out to evaluate BMD. Further prospective studies are required to establish guidelines. However, it seems reasonable to monitor women with POF yearly for the presence of any endocrine dysfunction and to assess BMD at periodic intervals.
Key words:  Premature ovarian failure      Bone mineral density      Osteoporosis      Bone turnover markers     
Published:  10 April 2014     
*Corresponding Author(s):  E. BASTU     E-mail:  ercan.bastu@istanbul.edu.tr

Cite this article: 

N. Kurtoglu-Aksoy, S.E. Akhan, E. Bastu, F. Gungor-Ugurlucan, A. Telci, A.C. Iyibozkurt, S. Topuz. Implications of premature ovarian failure on bone turnover markers and bone mineral density. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(2): 149-153.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog15802014     OR     https://ceog.imrpress.com/EN/Y2014/V41/I2/149

[1] R. Tachibana, H. Matsushita, A. Minami, N. Morita, S. Shimizu, H. Kanazawa, T. Suzuki, K. Watanabe, A. Wakatsuki. Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 546-551.
[2] F. N. Tuysuzoglu, G. A. Ilhan, B. Yildizhan. The impact of surgical menopause on metabolic syndrome, bone mineral density, and vasomotor symptoms[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 179-182.
[3] N. Morita, H. Matsushita, A. Minami, S. Shimizu, R. Tachibana, H. Kanazawa, T. Suzuki, K. Watanabe, A. Wakatsuki. Effect of the methanol extract of the Lion’s Mane mushroom, Hericium erinaceus, on bone metabolism in ovariectomized rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 47-52.
[4] Ö. Murat, Ç. Önder. The effects of exogenous melatonin administration on bone in ovariectomized and pinealectomized rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 933-937.
[5] Y. Wu, L. Tong, L. Xiao. Artificial neural network models for prediction of premature ovarian failure[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 958-963.
[6] H.A. Mansouri. Do bone turnover markers change with a steep drop in maternal steroids?[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 784-786.
[7] He Hu, Guowei Zhang, Geng Tian, Guang Lv, Yongli Jin. miRNA profiling reveals the upregulation of osteogenesis-associated miRNAs in ovariectomy osteoporosis mice[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(6): 817-822.
[8] Jung Yeob Seoung, Suk Woo Lee, Young Mo Kang, Min Jung Kim, Jae Min Park, Hye Min Moon, Chae Chun Rhim. Association between metabolic risks and bone mineral density in postmenopausal women[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 671-676.
[9] R. Słopień, S. Khadka, M. Englert-Golon, M. Pisarska-Krawczyk, S. Sajdak. Is there a place for menopausal hormonal therapy in the treatment of postmenopausal osteoporosis?[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(3): 325-327.
[10] J. H. Check, R. Cohen. A second successful pregnancy using oocytes from a woman with premature ovarian failure with embryos transferred to a gestational carrier[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 507-508.
[11] J.H. Check, R. Cohen, K. Mccullen, J. Mitchell-Williams. Sexual infantilism in a normal karotypic female related to ovarian agenesis associated with Mullerian agenesis – Case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(4): 535-536.
[12] Hui Chen, Xue Xiao, Dan Shan, Wenjuan Li, Yanbiao Liao, Liangzhi Xu. Platelet-activating factor acetylhydrolase and premature ovarian failure[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(6): 613-616.
[13] R. Słopien, A. Warenik-Szymankiewicz. Premature ovarian failure: diagnosis and treatment[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(6): 659-661.
[14] A. Warenik-Szymankiewicz, R. Słopień. Pregnancy in a patient with premature ovarian failure[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(3): 341-342.
[15] D. Caserta, G. Bordi, V. Giovanale, M. Moscarini. Premature ovarian failure in a 17-year-old woman[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(2): 223-225.
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